ENHANCING CHEMOIMMUNOTHERAPY FOR COLORECTAL CANCER WITH PACLITAXEL AND ALANTOLACTONE VIA CD44-TARGETED NANOPARTICLES: A STAT3 SIGNALING PATHWAY MODULATION APPROACH

Chemoimmunotherapy has the potential to enhance chemotherapy and modulate the immunosuppressive tumor microenvironment by activating immunogenic cell death (ICD), making it a promising strategy for clinical application.Alantolactone (A) was found to augment the anticancer efficacy of paclitaxel (P) at a molar ratio of 1:0.5 (P:A) through induction

The remodeling of the left atrial morphology and function caused by atrial fibrillation (AF) can exacerbate thrombosis in the left atrium (LA) even spike up the risk of stroke within AF patients.This study explored the effect of the AF on hemodynamic and thrombosis in LA.We reconstructed the patient-specific anatomical shape of the LA and STRENGTHE